Paradigm BioCapital Advisors provides portfolio management for pooled vehicles. The firm advises 2 private funds.
Paradigm BioCapital Advisors reports 4 clients. They include 3 pooled investment vehicles and 1 other client. Of its assets, 100.0% ($4.47B across 4 accounts) are managed with discretion. Of its clients, 50% are outside the U.S.
| Client type | Clients | Assets |
|---|---|---|
| Pooled investment vehicles | 75% | 90% |
| Other | 25% | 10% |
Client breakdown and activity details
| Client type | Clients | Regulatory AUM | AUM share | Avg. per client |
|---|---|---|---|---|
| Pooled investment vehicles | 3 | $4B | 89.6% | $1.33B |
| Other | Fewer than 5 | $465M | 10.4% | $465M |
| Total | 4 | $4.47B | 100% | — |
- Clients
- 3
- Regulatory AUM
- $4B
- AUM share
- 89.6%
- Avg. per client
- $1.33B
- Clients
- Fewer than 5
- Regulatory AUM
- $465M
- AUM share
- 10.4%
- Avg. per client
- $465M
Total
- Clients
- 4
- Regulatory AUM
- $4.47B
- AUM share
- 100%
- Avg. per client
- —
- Clients outside the U.S.
- 50%
- Clients advised without assets under management last fiscal year
- 0
- Private funds advised
- 2
Paradigm BioCapital Advisors is paid through a percentage of assets under management and performance-based fees; its fees and minimums are set out in its brochures on the SEC website.
DR. Senai Asefaw owns 75% or more of Paradigm BioCapital Advisors. The leadership team of Paradigm BioCapital Advisors includes Chief Investment Officer DR. Senai Asefaw and Chief Operating Officer David Kim. It has 11 employees, 6 of them in advisory roles.
Staff
- 11 employees
- 6 in advisory functions
- Owns 75% or more of Paradigm Biocapital Advisors LP
DR. Senai Asefaw
Control person · since December 2020
Paradigm BioCapital Advisors’ regulatory assets grew 34.6× from $129M (June 2021) to $4.47B (August 2026); clients rose from 3 to 4 and employees from 4 to 11.
Figures from each annual filing
| Filed | Regulatory AUM | Clients | StaffEmployees | Offices |
|---|---|---|---|---|
| Aug 2026August 2026 | $4.47B | 4 | 11 | 1 |
| Mar 2025March 2025 | $3.05B | 4 | 9 | 1 |
| Mar 2024March 2024 | $2.36B | 4 | 8 | 1 |
| Mar 2023March 2023 | $933M | 4 | 7 | 1 |
| Mar 2022March 2022 | $401M | 3 | 6 | 1 |
| Jun 2021June 2021 | $129M | 3 | 4 | 1 |
Besides its headquarters, Paradigm BioCapital Advisors has 0 offices, with 1 listed address in 1 state.
New York · 1 listed address
- 520 Fifth Avenue, 23rd Floor, New YorkHQ
Contact and registration details
- Legal name
- Paradigm Biocapital Advisors LP
- Headquarters
- 520 Fifth Avenue, 23rd Floor, New York, NY 10036
- Website
- paradigmbiocapital.com
- Phone
- 646-970-2568
- @paradigm-biocapital
- SEC file
- 801-120338
- Structure
- Delaware limited partnership
- Fiscal year end
- December
Paradigm BioCapital Advisors’ named custodians for separately managed accounts are Morgan Stanley ($233M, 52%), J.P. Morgan ($123M, 27%) and Merrill Lynch Professional Clearing ($94.9M, 21%). Paradigm BioCapital Advisors has custody of $4B for 3 clients.
- Morgan StanleyMorgan Stanley & Co. LLC · New York, NY · $233M52%
- J.P. MorganJ.P. Morgan Securities LLC · New York, NY · $123M27%
- Merrill Lynch Professional ClearingMerrill Lynch Professional Clearing Corp. · New York, NY · $94.9M21%
At year end, Paradigm BioCapital Advisors’ separately managed accounts were mostly in stocks (97%). Its reported 13F holdings for the quarter ended 30 June 2026 total $5.34B across 28 positions; the largest are Revolution Medicines Inc. (22.3%), Nuvalent Inc. (13.7%) and Edgewise Therapeutics Inc. (7.8%).
What the accounts hold
- Stocks97%
- Exchange-traded equities95%
- Non-exchange-traded equities2%
- Cash3%
How many clients does Paradigm BioCapital Advisors have?
Paradigm BioCapital Advisors has 4 clients and manages $4.47 billion for them, as of August 2026. They include 3 pooled investment vehicles and 1 other client.
Source: Form ADV Part 1A, Items 5.D and 5.F, filed 27 August 2026
What services does Paradigm BioCapital Advisors offer?
Paradigm BioCapital Advisors provides portfolio management for pooled vehicles.
Source: Form ADV Part 1A, Item 5.G, from the SEC's 2 October 2026 data file
Which custodians does Paradigm BioCapital Advisors use?
Paradigm BioCapital Advisors’ separately managed account assets are held at Morgan Stanley & Co. LLC (New York, NY), with $233M, J.P. Morgan Securities LLC (New York, NY), with $123M and Merrill Lynch Professional Clearing Corp. (New York, NY), with $94.9M. Only custodians holding at least a tenth of those assets are named.
Source: Form ADV Part 1A, Schedule D, Section 5.K.(3), filed 27 August 2026
How many financial advisors does Paradigm BioCapital Advisors have?
Paradigm BioCapital Advisors has 0 investment adviser representatives registered with state securities authorities, out of 11 employees, and 6 perform investment advisory functions. None are registered representatives of a broker-dealer or licensed insurance agents.
Source: Form ADV Part 1A, Items 5.A and 5.B, from the SEC's 2 October 2026 data file
What does Paradigm BioCapital Advisors invest in?
At the end of its last fiscal year, Paradigm BioCapital Advisors’ separately managed accounts held 95% exchange-traded equities, 3% cash and equivalents and 2% non-exchange-traded equities. It advises 2 private funds.
Source: Form ADV Part 1A, Items 5.K.(1) and 7.B, from the SEC's 2 October 2026 data file
Who owns Paradigm BioCapital Advisors?
Paradigm BioCapital Advisors’ direct owner is DR. Senai Asefaw (75% or more).
Source: Form ADV Part 1A, Schedules A and B, filed 27 August 2026
How does Paradigm BioCapital Advisors get paid?
Paradigm BioCapital Advisors is paid through a percentage of assets under management and performance-based fees. Its Form ADV lists no commissions among how it is paid.
Source: Form ADV Part 1A, Item 5.E, from the SEC's 2 October 2026 data file
How do I contact Paradigm BioCapital Advisors?
Paradigm BioCapital Advisors’ main office is at 520 Fifth Avenue, 23rd Floor, New York, NY 10036. Its phone number is 646-970-2568. Its website is paradigmbiocapital.com.